Priemel M, von Domarus C, Klatte In order to mais aussi al
Limbs mineralization defects and you can supplement D insufficiency: histomorphometric studies from iliac crest bones biopsies and circulating 25-hydroxyvitamin D inside the 675 customers. J Bones Miner Res 2010; 25: 305–312.
Zhou Y, Zhao LJ, Xu X ainsi que al. DNA methylation amounts of CYP2R1 and CYP24A1 assume nutritional D effect adaptation. J Steroid Biochem Mol Biol 2014; 144: 207–214.
Ralston SH, Binkley N, Boonen S ainsi que al. Randomized demonstration off alendronate as well as supplement D3 instead of practical worry when you look at the osteoporotic postmenopausal people which have vitamin D deficiency. Calcif Cells Int 2011; 88: 485–494.
Weber K, Kaschig C, Erben RG . step 1 Alpha-hydroxyvitamin D2 and 1 leader-hydroxyvitamin D3 enjoys anabolic outcomes to your cortical limbs, however, create intracortical renovations on dangerous doses when you look at the ovariectomized rats. Limbs 2004; 35: 704–710.
Li Meters, Healy DR, Simmons HA ainsi que al. Alfacalcidol regulates cancellous bone into the ovariectomized mice. J Musculoskelet Neuronal Interact 2003; 3: 39–46.
Treatment which have elage, and you will collagen crosslinks into the primate bone
Orimo H, Shiraki Yards, Hayashi Y mais aussi al. Effects of step one alpha-hydroxyvitamin D3 towards lumbar limbs mineral occurrence and you may spine breaks from inside the people that have postmenopausal osteoporosis. Calcif Tissue Int 1994; 54: 370–376.
Shikari Kushida M, Yamazaki K, Nagai K et al. H. Aftereffects of dos years’ treatments for osteoporosis that have step one leader-hydroxy supplement D3 into the bone nutrient thickness and you can chance from fracture: an excellent placebo-regulated, double-blind possible analysis. Endocr J 1996; 43: 211–220.
Nuti Roentgen, Bianchi Grams, Brandi ML et al. Excellence away from alfacalcidol compared to the vitamin D including calcium inside lumbar bones nutrient occurrence within the postmenopausal weakening of bones. Rheumatol Int 2006; 26: 445–453.
Kubodera N, Tsuji N, Uchiyama Y et al. Yet another effective supplement D analogue, ED-71, causes upsurge in bones bulk that have preferential consequences into limbs into the osteoporotic patients. J Mobile Biochem 2003; 88: 286–289.
Abe Yards, Tsuji Letter, Takahashi F et al. Review of the fresh new health-related pharmacokinetics off elin D3 by-product. Jpn Pharmacol Ther 2011; 39: 261–274.
Ritter CS, Brown AJ . Suppression out of PTH because of the nutritional D analog eldecalcitol is modulated by its high affinity to the serum vitamin D-joining proteins and you will resistance to kcalorie burning. J Telephone Biochem 2011; 112: 1348–1352.
Kondo S, Takano T, Ono Y ainsi que al. Eldecalcitol reduces osteoporotic breaks from the unique mechanisms. J Steroid Biochem Mol Biol 2015; 148: 232–238.
Harada S, Mizoguchi T, Kobayashi Y et al. Each day government out of elin D analogue, develops bones mineral thickness of the inhibiting RANKL term in the mouse trabecular bones. J Bones Miner Res 2012; 27: 461–473.
Hayashi Y, Fujita T, Inoue T
Matsumoto T, Ito Meters, Hayashi Y mais aussi al. A separate productive vitamin D3 analog, eldecalcitol, prevents the possibility of osteoporotic breaks–an effective randomized, energetic comparator, double-blind research. Bones 2011; 49: 605–612.
Matsumoto T, Takano T, Saito H mais aussi al. Nutritional D analogs and you will bone: preclinical and you will scientific studies that have este; 3: 513.
Sakai A beneficial, Ito Meters, Tomomitsu T et al. Effectiveness regarding shared procedures with alendronate (ALN) and you can elin D analogue, to this out-of concomitant ALN, vitamin D including calcium cures from inside the Japanese clients that have pri; 26: 1193–1202.
Plum Los angeles, Fitzpatrick Los angeles, Ma X et al. 2MD, an alternative anabolic representative for weakening of bones procedures. Osteoporos Int 2006; 17: 704–715.
Ke HZ, Qi www.datingranking.net/portuguese-chat-room/ H, Crawford DT mais aussi al. A unique nutritional D analog, 2MD, restores trabecular and cortical limbs bulk and you may stamina from inside the ovariectomized mice having oriented osteopenia. J Bones Miner Res 2005; 20: 1742–1755.
DeLuca HF, Bedale W, Binkley N et al. The fresh new vitamin D analog 2MD expands bone return however BMD for the postmenopausal female with osteopenia: outcome of a-1-seasons stage 2 double-blind, placebo-controlled, randomized clinical trial. J Bones Miner Res 2011; 26: 538–545.